Endocrine Abstracts

Hypothyroid patients with gastric disorders require a higher dose of oral thyroxine (T4) to reach target serum TSH. In vitro evidence supports the notion that the variations of gastric pH may also interfere with T4 dissolution profile. The present study is aimed at confirming in vivo the supposed correlation between the gastric pH, directly measured during endoscopy, and the therapeutic dose of thyroxine using a controlled treatment schedule. A total of 61 tablet T4-t...

Background: HIV-infected patients are predisposed to an increased risk of hyponatremia. In healthy population, low sodium is associated with impaired health status and reduced BMD, but less is known about this association in HIV-infection.Aim: To investigate the relationship between serum sodium, frailty and BMD in a large cohort of HIV-infected patients.Methodology: A retrospective, observational, cohort study on adult HIV-infecte...

BackgroundIn lipodystrophy (LD) adipose tissue function is impaired, leading to a severe metabolic syndrome. Familiar Partial LD (FPLD) type I (Kobberling Syndrome) overlaps with Cushing’s syndrome phenotype. The latter and the metabolic impairment observed in FPLD1 may suggest a crosstalk between the HPA axis, assuming that leptin sensitivity is preserved in this context. We aimed to evaluate if leptin levels are associated with glucocorticoid acti...

IntroductionIrisin is a molecule secreted from skeletal muscle and contributes to maintenance of metabolic homeostasis leading to increased energy expenditure and reducing the risk of obesity and diabetes. Literature data suggest that patients with Cushing disease have lower irisin values than controls and remission of hypercortisolism increases these values. Moreover, other plasma inflammation markers implicated in the pathogenesis of atherosclerosis, i...

IntroductionThyroid diseases affect a large population worldwide and total thyroidectomy (TT) is the most common curative treatment [1]. Recurrent laryngeal nerve (RLN) lesions are the most dangerous complication [1]. The intraoperative neuromonitoring (NIM) is a useful tool in reducing the incidence of nerve injury, but a preoperative examinations of vocal cords function through flexible fiberoptic laryngoscopy (FFL) is recommended [1]. FFL is uncomfort...

BackgroundThe incidence of papillary thyroid cancers is increase in last decades due to easier ultrasound diagnosis. The papillary thyroid cancers metastasize via lymphatics to the lymph nodes of the central and later cervical neck compartment. According to 2015 ATA guidelines, the recurrence rate is less 1–2% [2]. The treatment of choice in lymph node recurrences is surgery, but it is burdened by a higher rate of complications (25% of recurrent lar...

Background: Ultrasound guided minimally invasive therapies are becoming increasingly popular for the treatment of symptomatic benign thyroid nodules. Efforts have been directed on the prediction of volume reduction as a measure of efficacy of the procedure. Aim of the present study is to identify predictors of 6-months volume reduction rate (VRR) after radiofrequency ablation of benign thyroid nodules.Materials and Methods: We performed a retrospective s...

Context: A variety of thyroid disorders have been documented in COVID-19 patients, including non-thyroidal illness syndrome (NTIS), subacute thyroiditis (SAT) and thyrotoxicosis.Objectives: To investigate the relationship between thyroid dysfunctions observed during hospitalisation and COVID-19-related morbidity and mortality.Study design and setting: Prospective cohort study on patients admitted in a tertiary hospital for COVID-19...

Background and Objective: In thyroid cancer (TC) central compartment (CC) neck dissection (CCND) should accompany thyroidectomy in case of clinical and/or cytological suspicion of lymph node (LN) metastases. Cervical ultrasound has been indicated as the first-line examination in the pre-operative staging of TC, although its diagnostic performance in evaluating CC LN is controversial. Proving that cervical ultrasound can accurately identify CC metastases would allow to use this...

Introduction: While searching for mechanisms contributing to the increased mortality of acromegaly, we have previously described an unexpected sympathoinhibition in newly diagnosed patients (Seravalle et al., Clin Endocrinol 77:262, 2012) and interpreted this finding as an adaptive phenomenon. It has also been shown that centrally administered somatostatin (SS) inhibits peripheral sympathetic outflow in rodents (Rettig et al., Am J Physiol 257:R588, 1989). Ba...